articleNew England Journal of MedicineJun 25, 2008BRONZE OA

Polygenes, Risk Prediction, and Targeted Prevention of Breast Cancer

PDPaul D.P. PharoahACAntonis C. AntoniouDFDouglas F. EastonBABruce A.J. Ponder

University of Cambridge · Scientific Committee on Antarctic Research · +1 more institution

PubMed
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Abstract

Background

New developments in the search for susceptibility alleles in complex disorders provide support for the possibility of a polygenic approach to the prevention and treatment of common diseases.

Methods

We examined the implications, both for individualized disease prevention and for public health policy, of findings concerning the risk of breast cancer that are based on common genetic variation.

Citation impact

621
total citations
FWCI
40.70
Percentile
100%
References
32
Citations per year

Authors

4

Topics & keywords

Topics
Keywords
  • Medicine
  • Breast cancer
  • Penetrance
  • Context (archaeology)
  • Multifactorial Inheritance
  • Population
  • Disease
  • Allele
UN Sustainable Development Goals
  • Good health and well-being
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