The ADAMs family of metalloproteases: multidomain proteins with multiple functions
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Abstract
The ADAMs family of transmembrane proteins belongs to the zinc protease superfamily. Members of the family have a modular design, characterized by the presence of metalloprotease and integrin receptor-binding activities, and a cytoplasmic domain that in many family members specifies binding sites for various signal transducing proteins. The ADAMs family has been implicated in the control of membrane fusion, cytokine and growth factor shedding, and cell migration, as well as processes such as muscle development, fertilization, and cell fate determination. Pathologies such as inflammation and cancer also involve ADAMs family members. Excellent reviews covering various facets of the ADAMs literature-base have…
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Topics
Keywords
- Biology
- Transmembrane protein
- Protein family
- Cell biology
- Metalloproteinase
- Transmembrane domain
- Computational biology
- Disintegrin
UN Sustainable Development Goals
- Good health and well-being
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