SF3B1  and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia

Wang, Lili; Lawrence, Michael S.; Wan, Youzhong; Stojanov, Petar; Sougnez, Carrie; Stevenson, Kristen; Werner, Lillian; Sivachenko, Andrey; DeLuca, David S.; Zhang, Li; Zhang, Wandi; Vartanov, Alexander R.; Fernandes, Stacey M.; Goldstein, Natalie R.; Folco, Eric G.; Cibulskis, Kristian; Tesar, Bethany; Sievers, Quinlan; Shefler, Erica; Gabriel, Stacey; Hacohen, Nir; Reed, Robin; Meyerson, Matthew; Golub, Todd R.; Lander, Eric S.; Neuberg, Donna; Brown, Jennifer R.; Getz, Gad; Wu, Catherine J.

doi:10.1056/nejmoa1109016

articleNew England Journal of MedicineDec 12, 2011BRONZE OA

SF3B1 and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia

LWLili Wang MSMichael S. Lawrence YWYouzhong Wan PSPetar Stojanov CSCarrie Sougnez

Dana-Farber Cancer Institute · Broad Institute · +4 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Background

The somatic genetic basis of chronic lymphocytic leukemia, a common and clinically heterogeneous leukemia occurring in adults, remains poorly understood.

Methods

We obtained DNA samples from leukemia cells in 91 patients with chronic lymphocytic leukemia and performed massively parallel sequencing of 88 whole exomes and whole genomes, together with sequencing of matched germline DNA, to characterize the spectrum of somatic mutations in this disease.

Citation impact

1,065

total citations

FWCI: 54.90
Percentile: 100%
References: 36

Citations per year

Authors

29

Topics & keywords

Topics

Keywords

Chronic lymphocytic leukemia
Leukemia
Spliceosome
Germline
Somatic cell
Germline mutation
Cancer research
RNA splicing

UN Sustainable Development Goals

Good health and well-being

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