antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers
University of Tübingen · QB3 · +3 more institutions
Abstract
Microbial secondary metabolites are a potent source of antibiotics and other pharmaceuticals. Genome mining of their biosynthetic gene clusters has become a key method to accelerate their identification and characterization. In 2011, we developed antiSMASH, a web-based analysis platform that automates this process. Here, we present the highly improved antiSMASH 2.0 release, available at http://antismash.secondarymetabolites.org/. For the new version, antiSMASH was entirely re-designed using a plug-and-play concept that allows easy integration of novel predictor or output modules. antiSMASH 2.0 now supports input of multiple related sequences simultaneously (multi-FASTA/GenBank/EMBL), which allows the analysis…
Citation impact
- FWCI
- 126.41
- Percentile
- 100%
- References
- 33
Authors
7- KBKai BlinCorresponding
University of Tübingen
- MHMarnix H. Medema
QB3, Biotechnology Institute, University of Groningen, University of California, San Francisco
- DKDaniyal Kazempour
QB3, Biotechnology Institute, University of Groningen, University of California, San Francisco, University of Tübingen
- MAMichael A. Fischbach
QB3, Biotechnology Institute, University of Groningen, University of California, San Francisco
- RBRainer Breitling
QB3, Biotechnology Institute, University of Groningen, University of California, San Francisco
Topics & keywords
- Biology
- Genome
- GenBank
- Computational biology
- Polyketide
- Secondary metabolite
- Identification (biology)
- Gene