Posterior cortical atrophy
UK Dementia Research Institute · University College London · +1 more institution
Abstract
Posterior cortical atrophy (PCA) is a neurodegenerative syndrome that is characterised by progressive decline in visuospatial, visuoperceptual, literacy, and praxic skills. The progressive neurodegeneration affecting parietal, occipital, and occipitotemporal cortices that underlies PCA is attributable to Alzheimer's disease in most patients. However, alternative underlying causes, including dementia with Lewy bodies, corticobasal degeneration, and prion disease, have also been identified, and not all patients with PCA have atrophy on clinical imaging. This heterogeneity has led to inconsistencies in diagnosis and terminology and difficulties in comparing studies from different centres, and has restricted the…
Citation impact
- FWCI
- 23.21
- Percentile
- 100%
- References
- 121
Authors
6- SJSebastian J. CrutchCorresponding
UK Dementia Research Institute, University College London
- MLManja Lehmann
University Memory and Aging Center, University College London, UK Dementia Research Institute
- JMJonathan M. Schott
University College London, UK Dementia Research Institute
- GDGil D. Rabinovici
University Memory and Aging Center
- MNMartin N. Rossor
UK Dementia Research Institute, University College London
Topics & keywords
- Posterior cortical atrophy
- Corticobasal degeneration
- Atrophy
- Progressive supranuclear palsy
- Disease
- Dementia
- Neuroscience
- Neurodegeneration
- Quality Education
Funding
- AAAlzheimer's AssociationAward: K23-AG031861
- ASAlzheimer's Society
- JDJohn Douglas French Alzheimer's Foundation
- NINational Institute for Health and Care Research
- UCUniversity College London
- UCUniversity College London Hospitals NHS Foundation Trust
- NINational Institutes of HealthAward: [NIA K23-AG031861 (PI)]
- MRMedical Research Council
- NINational Institute on AgingAwards: NIA K23-AG031861, K23-AG031861