Highly Pathogenic H5N1 Influenza Virus Infection in Migratory Birds
Chinese Academy of Sciences · Academy of Military Medical Sciences · +3 more institutions
Abstract
H5N1 avian influenza virus (AIV) has emerged as a pathogenic entity for a variety of species, including humans, in recent years. Here we report an outbreak among migratory birds on Lake Qinghaihu, China, in May and June 2005, in which more than a thousand birds were affected. Pancreatic necrosis and abnormal neurological symptoms were the major clinical features. Sequencing of the complete genomes of four H5N1 AIV strains revealed them to be reassortants related to a peregrine falcon isolate from Hong Kong and to have known highly pathogenic characteristics. Experimental animal infections reproduced typical highly pathogenic AIV infection symptoms and pathology.
Citation impact
- FWCI
- 40.46
- Percentile
- 100%
- References
- 5
Authors
14- JLJing LiuCorresponding
Chinese Academy of Sciences, Academy of Military Medical Sciences, Institute of Microbiology, Institute of Zoology, China Agricultural University
- HXHui XiaoCorresponding
Chinese Academy of Sciences, Academy of Military Medical Sciences, Institute of Microbiology, Institute of Zoology, China Agricultural University
- FLFumin LeiCorresponding
Chinese Academy of Sciences, Academy of Military Medical Sciences, Institute of Microbiology, Institute of Zoology, China Agricultural University
- QZQiuying Zhu
Chinese Academy of Sciences, Academy of Military Medical Sciences, Institute of Microbiology, Institute of Zoology, China Agricultural University
- KQKun Qin
Chinese Academy of Sciences, Academy of Military Medical Sciences, Institute of Microbiology, Institute of Zoology, China Agricultural University
Topics & keywords
- Influenza A virus subtype H5N1
- Highly pathogenic
- Outbreak
- Biology
- Virology
- Virus
- Avian influenza virus
- Influenza A virus
- Life below water