limma powers differential expression analyses for RNA-sequencing and microarray studies
University of Melbourne · Walter and Eliza Hall Institute of Medical Research · +4 more institutions
Abstract
Limma is an R/Bioconductor software package that provides an integrated solution for analysing data from gene expression experiments. It contains rich features for handling complex experimental designs and for information borrowing to overcome the problem of small sample sizes. Over the past decade, limma has been a popular choice for gene discovery through differential expression analyses of microarray and high-throughput PCR data. The package contains particularly strong facilities for reading, normalizing and exploring such data. Recently, the capabilities of limma have been significantly expanded in two important directions. First, the package can now perform both differential expression and differential…
Citation impact
- FWCI
- 596.58
- Percentile
- 100%
- References
- 95
Authors
7- MEMatthew E. Ritchie
University of Melbourne, Walter and Eliza Hall Institute of Medical Research
- BPBelinda Phipson
Royal Children's Hospital, Murdoch Children's Research Institute
- DWDi Wu
Harvard University
- YHYifang Hu
Walter and Eliza Hall Institute of Medical Research
- CWCharity W. Law
University of Zurich
Topics & keywords
- Biology
- Bioconductor
- Computational biology
- DNA microarray
- Microarray analysis techniques
- Gene chip analysis
- Expression (computer science)
- Data mining