Enzyme-responsive nanomaterials for controlled drug delivery

Enzymes underpin physiological function and exhibit dysregulation in many disease-associated microenvironments and aberrant cell processes. Exploiting altered enzyme activity and expression for diagnostics, drug targeting, and drug release is tremendously promising. When combined with booming research in nanobiotechnology, enzyme-responsive nanomaterials used for controlled drug release have achieved significant development and have been studied as an important class of drug delivery strategies in nanomedicine. In this review, we describe enzymes such as proteases, phospholipases and oxidoreductases that serve as delivery triggers. Subsequently, we explore recently developed enzyme-responsive nanomaterials…

• AD
  American Diabetes Association
• NC
  North Carolina State University
• NI
  National Institutes of Health
• NI
  National Institute of General Medical Sciences
• NC
  North Carolina Translational and Clinical Sciences Institute, University of North Carolina at Chapel Hill