Inhibition of plaque neovascularization reduces macrophage accumulation and progression of advanced atherosclerosis
Boston University · Brigham and Women's Hospital · +1 more institution
Abstract
Plaque angiogenesis promotes the growth of atheromas, but the functions of plaque capillaries are not fully determined. Neovascularization may act as a conduit for the entry of leukocytes into sites of chronic inflammation. We observe vasa vasorum density correlates highly with the extent of inflammatory cells, not the size of atheromas in apolipoprotein E-deficient mice. We show atherosclerotic aortas contain activities that promote angiogenesis. The angiogenesis inhibitor angiostatin reduces plaque angiogenesis and inhibits atherosclerosis. Macrophages in the plaque and around vasa vasorum are reduced, but we detect no direct effect of angiostatin on monocytes. After angiogenesis blockade in vivo, the…
Citation impact
- FWCI
- 15.46
- Percentile
- 100%
- References
- 32
Authors
10- KSKaren S. MoultonCorresponding
Boston University, Brigham and Women's Hospital, Harvard University
- KVKhashayar Vakili
Boston University, Brigham and Women's Hospital, Harvard University
- DZDavid Zurakowski
Boston University, Brigham and Women's Hospital, Harvard University
- MSMohsin Soliman
Boston University, Brigham and Women's Hospital, Harvard University
- CBCatherine Butterfield
Boston University, Brigham and Women's Hospital, Harvard University
Topics & keywords
- Angiogenesis
- Angiostatin
- Vasa vasorum
- Neovascularization
- Inflammation
- Macrophage
- Cancer research
- Cell biology
- Good health and well-being