Deep Brain Stimulation of the Nucleus Accumbens for Treatment-Refractory Obsessive-Compulsive Disorder

Denys, Damiaan; Mantione, Mariska; Figee, Martijn; Munckhof, Pepijn van den; Koerselman, Frank; Westenberg, H.G.M.; Bosch, Andries; Schuurman, Rick

doi:10.1001/archgenpsychiatry.2010.122

articleArchives of General PsychiatryOct 4, 2010Closed access

Deep Brain Stimulation of the Nucleus Accumbens for Treatment-Refractory Obsessive-Compulsive Disorder

DDDamiaan Denys MMMariska Mantione MFMartijn Figee PVPepijn van den Munckhof FKFrank Koerselman

University of Amsterdam · Academic Medical Center

PubMed

Indexed incrossrefpubmed

Abstract

Objective

To determine whether bilateral deep brain stimulation of the nucleus accumbens is an effective and safe treatment for treatment-refractory OCD.

Design

The study consisted of an open 8-month treatment phase, followed by a double-blind crossover phase with randomly assigned 2-week periods of active or sham stimulation, ending with an open 12-month maintenance phase.

Citation impact

753

total citations

FWCI: 45.67
Percentile: 100%
References: 19

Citations per year

Authors

8

Topics & keywords

Topics

Keywords

Deep brain stimulation
Nucleus accumbens
Stimulation
Refractory (planetary science)
Psychology
Crossover study
Depression (economics)
Population

UN Sustainable Development Goals

Good health and well-being

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