RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8 + T cells

Dying cells initiate adaptive immunity by providing both antigens and inflammatory stimuli for dendritic cells, which in turn activate CD8(+) T cells through a process called antigen cross-priming. To define how different forms of programmed cell death influence immunity, we established models of necroptosis and apoptosis, in which dying cells are generated by receptor-interacting protein kinase-3 and caspase-8 dimerization, respectively. We found that the release of inflammatory mediators, such as damage-associated molecular patterns, by dying cells was not sufficient for CD8(+) T cell cross-priming. Instead, robust cross-priming required receptor-interacting protein kinase-1 (RIPK1) signaling and nuclear…

• FC
  Francis Crick Institute
• CR
  Cancer Research UK
• AN
  Agence Nationale de la Recherche

  Award: ANR-12-BSV3-0011-01
• IN
  Institut National Du Cancer
• NI
  National Institutes of Health

  Awards: R21CA185681, AI44848, R01AI108685, 5R01AI108685-02
• HE
  H2020 European Research Council