articleJournal of Clinical InvestigationApr 16, 2009BRONZE OA

Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans

KLKimber L. StanhopeJMJean Marc SchwarzNLNancy L. KeimSCSteven C. GriffenAAAndrew A. Bremer

University of California, Davis · City College of San Francisco · +12 more institutions

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Abstract

Studies in animals have documented that, compared with glucose, dietary fructose induces dyslipidemia and insulin resistance. To assess the relative effects of these dietary sugars during sustained consumption in humans, overweight and obese subjects consumed glucose- or fructose-sweetened beverages providing 25% of energy requirements for 10 weeks. Although both groups exhibited similar weight gain during the intervention, visceral adipose volume was significantly increased only in subjects consuming fructose. Fasting plasma triglyceride concentrations increased by approximately 10% during 10 weeks of glucose consumption but not after fructose consumption. In contrast, hepatic de novo lipogenesis (DNL) and…

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Topics & keywords

Topics
Keywords
  • Internal medicine
  • Endocrinology
  • Postprandial
  • Fructose
  • Dyslipidemia
  • Insulin resistance
  • Lipogenesis
  • Triglyceride
UN Sustainable Development Goals
  • Affordable and clean energy
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