Cytoplasmic steps of peptidoglycan biosynthesis
Institut de Biochimie et Biophysique Moléculaire et Cellulaire · University of Ljubljana
Abstract
The biosynthesis of bacterial cell wall peptidoglycan is a complex process that involves enzyme reactions that take place in the cytoplasm (synthesis of the nucleotide precursors) and on the inner side (synthesis of lipid-linked intermediates) and outer side (polymerization reactions) of the cytoplasmic membrane. This review deals with the cytoplasmic steps of peptidoglycan biosynthesis, which can be divided into four sets of reactions that lead to the syntheses of (1) UDP-N-acetylglucosamine from fructose 6-phosphate, (2) UDP-N-acetylmuramic acid from UDP-N-acetylglucosamine, (3) UDP-N-acetylmuramyl-pentapeptide from UDP-N-acetylmuramic acid and (4) D-glutamic acid and dipeptide D-alanyl-D-alanine. Recent…
Citation impact
- FWCI
- 19.74
- Percentile
- 100%
- References
- 393
Authors
6Topics & keywords
- Peptidoglycan
- Biosynthesis
- Cytoplasm
- Biochemistry
- Lipid II
- Pentapeptide repeat
- Enzyme
- Biology