Antimicrobial strategies centered around reactive oxygen species – bactericidal antibiotics, photodynamic therapy, and beyond
Harvard University · Massachusetts General Hospital · +11 more institutions
Abstract
Reactive oxygen species (ROS) can attack a diverse range of targets to exert antimicrobial activity, which accounts for their versatility in mediating host defense against a broad range of pathogens. Most ROS are formed by the partial reduction in molecular oxygen. Four major ROS are recognized comprising superoxide (O2•-), hydrogen peroxide (H2O2), hydroxyl radical (•OH), and singlet oxygen ((1)O2), but they display very different kinetics and levels of activity. The effects of O2•- and H2O2 are less acute than those of •OH and (1)O2, because the former are much less reactive and can be detoxified by endogenous antioxidants (both enzymatic and nonenzymatic) that are induced by oxidative stress. In contrast,…
Citation impact
- FWCI
- 20.30
- Percentile
- 100%
- References
- 413
Authors
12- FVFatma Vatansever
Harvard University, Massachusetts General Hospital
- WCWanessa C. M. A. Melo
Universidade Federal de São Carlos, Universidade de São Paulo, Institute of Physics, Massachusetts General Hospital
- PAPinar Avci
Semmelweis University, Harvard University, Massachusetts General Hospital
- DVDaniela Vecchio
Harvard University, Massachusetts General Hospital
- MSMagesh Sadasivam
Amity University, Massachusetts General Hospital
Topics & keywords
- Reactive oxygen species
- Reactive nitrogen species
- Antimicrobial
- Hydrogen peroxide
- Antioxidant
- Singlet oxygen
- Oxidative stress
- Superoxide