Effect of Hydroxyurea on Mortality and Morbidity in Adult Sickle Cell Anemia
Boston University · Boston Medical Center · +24 more institutions
Indexed incrossrefpubmed
Abstract
Objective
To determine whether hydroxyurea attenuates mortality in patients with SCA.
Design
Long-term observational follow-up study of mortality in patients with SCA who originally participated in the randomized, double-blind, placebo-controlled Multicenter Study of Hydroxyurea in Sickle Cell Anemia (MSH), conducted in 1992-1995, to determine if hydroxyurea reduces vaso-occlusive events. In the MSH Patients' Follow-up, conducted in 1996-2001, patients could continue, stop, or start hydroxyurea. Data were collected during the trial and in the follow-up period.
Citation impact
895
total citations
- FWCI
- 21.18
- Percentile
- 100%
- References
- 37
Citations per year
Authors
27Topics & keywords
Topics
Keywords
- Medicine
- Acute chest syndrome
- Fetal hemoglobin
- Sickle cell anemia
- Hydroxycarbamide
- Anemia
- Internal medicine
- Placebo
UN Sustainable Development Goals
- Good health and well-being
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