Expanding GSK's solvent selection guide – embedding sustainability into solvent selection starting at medicinal chemistry

Henderson, Richard K.; Jiménez‐González, Concepción; Constable, David J. C.; Alston, Sarah R.; Inglis, Graham G. A.; Fisher, Gail; Sherwood, James; Binks, Steve P.; Curzons, Alan D.

doi:10.1039/c0gc00918k

articleGreen ChemistryJan 1, 2011Closed access

Expanding GSK's solvent selection guide – embedding sustainability into solvent selection starting at medicinal chemistry

RKRichard K. Henderson CJConcepción Jiménez‐González DJDavid J. C. Constable SRSarah R. Alston GGGraham G. A. Inglis

Research Triangle Park Foundation · Lockheed Martin (United States) · +2 more institutions

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Abstract

Solvents make a large contribution to the environmental impact of manufacturing processes of active pharmaceutical ingredients (API), as well as playing an important role in other chemical industries, with millions of tons used and disposed of each year. GlaxoSmithKline (GSK) has previously reported on the both the development of a GSK solvent selection guide and the incorporation of solvent life cycle inventory and assessment information. The GSK solvent selection guide has been further enhanced by:

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FWCI: 44.74
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Topics & keywords

Topics

Keywords

Solvent
Selection (genetic algorithm)
Life cycle inventory
Sustainability
Chemistry
Biochemical engineering
Life-cycle assessment
Organic chemistry

UN Sustainable Development Goals

Responsible consumption and production

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