Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity

Smythies, Lesley E.; Sellers, Marty T.; Clements, Ronald H.; Mosteller‐Barnum, Meg; Meng, Gang; Benjamin, William H.; Orenstein, Jan M.; Smith, Phillip D.

doi:10.1172/jci19229

articleJournal of Clinical InvestigationJan 3, 2005Closed access

Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity

LELesley E. Smythies MTMarty T. Sellers RHRonald H. Clements MMMeg Mosteller‐Barnum GMGang Meng

University of Alabama at Birmingham · American Society for Gastrointestinal Endoscopy · +3 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

Intestinal macrophages, which are thought to orchestrate mucosal inflammatory responses, have received little investigative attention compared with macrophages from other tissues. Here we show that human intestinal macrophages do not express innate response receptors, including the receptors for LPS (CD14), Fcalpha (CD89), Fcgamma (CD64, CD32, CD16), CR3 (CD11b/CD18), and CR4 (CD11c/CD18); the growth factor receptors IL-2 (CD25) and IL-3 (CD123); and the integrin LFA-1 (CD11a/CD18). Moreover, resident intestinal macrophages also do not produce proinflammatory cytokines, including IL-1, IL-6, IL-10, IL-12, RANTES, TGF-beta, and TNF-alpha, in response to an array of inflammatory stimuli but retain avid…

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786

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Topics & keywords

Topics

Keywords

Immunology
CD14
Integrin alpha M
Proinflammatory cytokine
Intestinal mucosa
Macrophage
Biology
CD11c

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