Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: Fabrication methods and transport studies
Georgia Institute of Technology · The Wallace H. Coulter Department of Biomedical Engineering
Abstract
Arrays of micrometer-scale needles could be used to deliver drugs, proteins, and particles across skin in a minimally invasive manner. We therefore developed microfabrication techniques for silicon, metal, and biodegradable polymer microneedle arrays having solid and hollow bores with tapered and beveled tips and feature sizes from 1 to 1,000 microm. When solid microneedles were used, skin permeability was increased in vitro by orders of magnitude for macromolecules and particles up to 50 nm in radius. Intracellular delivery of molecules into viable cells was also achieved with high efficiency. Hollow microneedles permitted flow of microliter quantities into skin in vivo, including microinjection of insulin to…
Citation impact
- FWCI
- 20.69
- Percentile
- 100%
- References
- 29
Authors
7- DVDevin V. McAllisterCorresponding
Georgia Institute of Technology, The Wallace H. Coulter Department of Biomedical Engineering
- PMPing M. Wang
Georgia Institute of Technology, The Wallace H. Coulter Department of Biomedical Engineering
- SPShawn P. Davis
Georgia Institute of Technology, The Wallace H. Coulter Department of Biomedical Engineering
- JPJung‐Hwan Park
Georgia Institute of Technology, The Wallace H. Coulter Department of Biomedical Engineering
- PJPaul J. Canatella
Georgia Institute of Technology, The Wallace H. Coulter Department of Biomedical Engineering
Topics & keywords
- Transdermal
- Materials science
- Microfabrication
- Nanotechnology
- Biomedical engineering
- Nanoparticle
- Fabrication