Pfam: the protein families database
Wellcome Sanger Institute · European Bioinformatics Institute · +6 more institutions
Abstract
Pfam, available via servers in the UK (http://pfam.sanger.ac.uk/) and the USA (http://pfam.janelia.org/), is a widely used database of protein families, containing 14 831 manually curated entries in the current release, version 27.0. Since the last update article 2 years ago, we have generated 1182 new families and maintained sequence coverage of the UniProt Knowledgebase (UniProtKB) at nearly 80%, despite a 50% increase in the size of the underlying sequence database. Since our 2012 article describing Pfam, we have also undertaken a comprehensive review of the features that are provided by Pfam over and above the basic family data. For each feature, we determined the relevance, computational burden, usage…
Citation impact
- FWCI
- 270.99
- Percentile
- 100%
- References
- 46
Authors
13- RFROBERT FINNCorresponding
Wellcome Sanger Institute, European Bioinformatics Institute, Science for Life Laboratory
- ABAlex Bateman
Science for Life Laboratory, Wellcome Trust, Wellcome Sanger Institute, European Bioinformatics Institute
- JCJody Clements
Science for Life Laboratory, European Bioinformatics Institute, Wellcome Sanger Institute, Janelia Research Campus
- PCPenelope Coggill
European Bioinformatics Institute, Science for Life Laboratory, Wellcome Trust, Wellcome Sanger Institute
- RYRuth Y. Eberhardt
Wellcome Trust, Science for Life Laboratory, European Bioinformatics Institute, Wellcome Sanger Institute
Topics & keywords
- UniProt
- Biology
- Context (archaeology)
- Computational biology
- Sequence database
- Protein family
- Proteome
- Protein sequencing