Differential network biology
University of California San Diego · La Jolla Bioengineering Institute · +3 more institutions
Abstract
Protein and genetic interaction maps can reveal the overall physical and functional landscape of a biological system. To date, these interaction maps have typically been generated under a single condition, even though biological systems undergo differential change that is dependent on environment, tissue type, disease state, development or speciation. Several recent interaction mapping studies have demonstrated the power of differential analysis for elucidating fundamental biological responses, revealing that the architecture of an interactome can be massively re-wired during a cellular or adaptive response. Here, we review the technological developments and experimental designs that have enabled differential…
Citation impact
- FWCI
- 39.90
- Percentile
- 100%
- References
- 84
Authors
2Topics & keywords
- Biology
- Interactome
- Biological network
- Systems biology
- Computational biology
- Interaction network
- Gene regulatory network
- Differential (mechanical device)