Colorectal-Cancer Incidence and Mortality with Screening Flexible Sigmoidoscopy

Schoen, Robert E.; Pinsky, Paul F.; Weissfeld, Joel L.; Yokochi, Lance; Church, Timothy R.; Laiyemo, Adeyinka O.; Bresalier, Robert S.; Andriole, Gerald L.; Buys, Saundra S.; Crawford, E. David; Fouad, Mona N.; Isaacs, Claudine; Johnson, Christine Cole; Reding, Douglas J.; O’Brien, Barbara; Carrick, Danielle M.; Wright, Patrick; Riley, Thomas L.; Purdue, Mark P.; Izmirlian, Grant; Kramer, Barnett S.; Miller, Anthony B.; Gohagan, John K.; Prorok, Philip C.; Berg, Christine D.

doi:10.1056/nejmoa1114635

articleNew England Journal of MedicineMay 21, 2012BRONZE OA

Colorectal-Cancer Incidence and Mortality with Screening Flexible Sigmoidoscopy

RERobert E. Schoen PFPaul F. Pinsky JLJoel L. Weissfeld LYLance Yokochi TRTimothy R. Church

University of Pittsburgh · UPMC Hillman Cancer Center · +21 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Background

The benefits of endoscopic testing for colorectal-cancer screening are uncertain. We evaluated the effect of screening with flexible sigmoidoscopy on colorectal-cancer incidence and mortality.

Methods

From 1993 through 2001, we randomly assigned 154,900 men and women 55 to 74 years of age either to screening with flexible sigmoidoscopy, with a repeat screening at 3 or 5 years, or to usual care. Cases of colorectal cancer and deaths from the disease were ascertained.

Citation impact

1,023

total citations

FWCI: 54.42
Percentile: 100%
References: 43

Citations per year

Authors

25

Topics & keywords

Topics

Keywords

Sigmoidoscopy
Medicine
Colorectal cancer
Incidence (geometry)
Relative risk
Internal medicine
Confidence interval
Cancer

UN Sustainable Development Goals

Good health and well-being

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