The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study at 30 Years: Overview

OBJECTIVE The Diabetes Control and Complications Trial (DCCT) was designed to test the glucose hypothesis and determine whether the complications of type 1 diabetes (T1DM) could be prevented or delayed. The Epidemiology of Diabetes Interventions and Complications (EDIC) observational follow-up determined the durability of the DCCT effects on the more-advanced stages of diabetes complications including cardiovascular disease (CVD). RESEARCH DESIGN AND METHODS The DCCT (1982-1993) was a controlled clinical trial in 1,441 subjects with T1DM comparing intensive therapy (INT), aimed at achieving levels of glycemia as close to the nondiabetic range as safely possible, with conventional therapy (CON), which aimed to…

• EL
  Eli Lilly and Company
• S
  Sanofi
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  BD
• RD
  Roche Diabetes Care
• AD
  Abbott Diabetes Care
• NE
  National Eye Institute
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  National Institute of Diabetes and Digestive and Kidney Diseases

  Awards: U01 DK094176, U01 DK094176 and U01 DK094157, U01 DK094157
• NI
  National Institute of Neurological Disorders and Stroke