articleThe Journal of Experimental MedicineSep 10, 2012BRONZE OA

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells

JMJonathan M. WeissAMAngelina M. BilateMGMichael GobertYDYi DingMAMaria A. Curotto de Lafaille

Howard Hughes Medical Institute · Institute of Biomedical Science · +6 more institutions

PubMed
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Abstract

Foxp3 activity is essential for the normal function of the immune system. Two types of regulatory T (T reg) cells express Foxp3, thymus-generated natural T reg (nT reg) cells, and peripherally generated adaptive T reg (iT reg) cells. These cell types have complementary functions. Until now, it has not been possible to distinguish iT reg from nT reg cells in vivo based solely on surface markers. We report here that Neuropilin 1 (Nrp1) is expressed at high levels by most nT reg cells; in contrast, mucosa-generated iT reg and other noninflammatory iT reg cells express low levels of Nrp1. We found that Nrp1 expression is under the control of TGF-β. By tracing nT reg and iT reg cells, we could establish that some…

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Topics & keywords

Topics
Keywords
  • Neuropilin 1
  • FOXP3
  • Biology
  • Immune system
  • Immunology
  • Cell biology
  • Cancer research
UN Sustainable Development Goals
  • Good health and well-being
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