Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation.
National Institutes of Health · National Institute of Arthritis and Musculoskeletal and Skin Diseases
Abstract
Recent advances in understanding the cellular and molecular signaling pathways and global transcriptional regulators of adult mesenchymal stem cells have provided new insights into their biology and potential clinical applications, particularly for tissue repair and regeneration. This review focuses on these advances, specifically in the context of self-renewal and regulation of lineage-specific differentiation of mesenchymal stem cells. In addition we review recent research on the concept of stem cell niche, and its relevance to adult mesenchymal stem cells.
Citation impact
- FWCI
- 21.15
- Percentile
- 100%
- References
- 96
Authors
3- CMCatherine M KolfCorresponding
National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases
- ECElizabeth Cho
National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health
- RSRocky S. Tuan
National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health
Topics & keywords
- Mesenchymal stem cell
- Biology
- Stem cell
- Cell biology
- Cellular differentiation
- Context (archaeology)
- Adult stem cell
- Clinical uses of mesenchymal stem cells