Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo
National Institutes of Health · University of California, Los Angeles · +10 more institutions
Abstract
Studies on the burden of human monkeypox in the Democratic Republic of the Congo (DRC) were last conducted from 1981 to 1986. Since then, the population that is immunologically naïve to orthopoxviruses has increased significantly due to cessation of mass smallpox vaccination campaigns. To assess the current risk of infection, we analyzed human monkeypox incidence trends in a monkeypox-enzootic region. Active, population-based surveillance was conducted in nine health zones in central DRC. Epidemiologic data and biological samples were obtained from suspected cases. Cumulative incidence (per 10,000 population) and major determinants of infection were compared with data from active surveillance in similar…
Citation impact
- FWCI
- 10.15
- Percentile
- 100%
- References
- 36
Authors
19- AWAnne W. RimoinCorresponding
National Institutes of Health, University of California, Los Angeles, Fogarty International Center
- PMPrime Mulembakani
Ministry of Public Health
- SCSara C. Johnston
United States Army Medical Research Institute of Infectious Diseases
- JOJames O. Lloyd‐Smith
National Institutes of Health, Fogarty International Center
- NKNeville K. Kisalu
University of California, Los Angeles
Topics & keywords
- Monkeypox
- Smallpox
- Vaccination
- Incidence (geometry)
- Population
- Medicine
- Smallpox vaccine
- Epidemiology
- Good health and well-being
Funding
- UDU.S. Department of Homeland Security
- USUnited States Agency for International Development
- WHWorld Health Organization
- SFSkoll Foundation
- NINational Institutes of Health
- SAScience and Technology Directorate
- FIFogarty International Center
- NINational Institute of Child Health and Human Development
- EKEunice Kennedy Shriver National Institute of Child Health and Human Development