11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment
University of Pittsburgh · Mayo Clinic · +2 more institutions
Abstract
To date, most diagnostic imaging comparisons between amyloid labelling ligands and other imaging modalities have been between the use of amyloid labelling ligand (11)C Pittsburgh Compound B (PiB) and FDG-PET. Our objectives were to compare cognitive performance and diagnostic group-wise discrimination between cognitively normal, amnestic mild cognitive impairment (MCI) and Alzheimer's disease subjects with MRI-based measures of hippocampal volume and PiB retention, and secondly to evaluate the topographic distribution of PiB retention and grey matter loss using 3D voxel-wise methods. Twenty cognitively normal, 17 amnestic MCI and 8 probable Alzheimer's disease subjects were imaged with both MRI and PiB. PiB…
Citation impact
- FWCI
- 39.38
- Percentile
- 100%
- References
- 102
Authors
11- CRClifford R. JackCorresponding
University of Pittsburgh, Mayo Clinic
- VJVal J. Lowe
Mayo Clinic, University of Pittsburgh
- MLMatthew L. Senjem
Information Management Services, Mayo Clinic, University of Pittsburgh
- SDStephen D. Weigand
Cancer Research And Biostatistics, University of Pittsburgh, Mayo Clinic
- BJBradley J. Kemp
Mayo Clinic, University of Pittsburgh
Topics & keywords
- Pittsburgh compound B
- Statistical parametric mapping
- Grey matter
- Alzheimer's disease
- Hippocampal formation
- Voxel
- Psychology
- Nuclear medicine
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