Isolation and Expansion of Adult Cardiac Stem Cells From Human and Murine Heart
Università Campus Bio-Medico · Mario Negri Institute for Pharmacological Research · +4 more institutions
Abstract
Cardiac myocytes have been traditionally regarded as terminally differentiated cells that adapt to increased work and compensate for disease exclusively through hypertrophy. However, in the past few years, compelling evidence has accumulated suggesting that the heart has regenerative potential. Recent studies have even surmised the existence of resident cardiac stem cells, endothelial cells generating cardiomyocytes by cell contact or extracardiac progenitors for cardiomyocytes, but these findings are still controversial. We describe the isolation of undifferentiated cells that grow as self-adherent clusters (that we have termed "cardiospheres") from subcultures of postnatal atrial or ventricular human biopsy…
Citation impact
- FWCI
- 24.95
- Percentile
- 100%
- References
- 32
Authors
14- EMElisa MessinaCorresponding
Università Campus Bio-Medico, Mario Negri Institute for Pharmacological Research, Istituto Neurologico Mediterraneo, IRCCS Ospedale San Raffaele, Institute of Neurobiology and Molecular Medicine, Sapienza University of Rome
- LDLuciana De Angelis
Università Campus Bio-Medico, Mario Negri Institute for Pharmacological Research, Istituto Neurologico Mediterraneo, IRCCS Ospedale San Raffaele, Institute of Neurobiology and Molecular Medicine, Sapienza University of Rome
- GFGiacomo Frati
Università Campus Bio-Medico, Mario Negri Institute for Pharmacological Research, Istituto Neurologico Mediterraneo, IRCCS Ospedale San Raffaele, Institute of Neurobiology and Molecular Medicine, Sapienza University of Rome
- SMStefania Morrone
Università Campus Bio-Medico, Mario Negri Institute for Pharmacological Research, Istituto Neurologico Mediterraneo, IRCCS Ospedale San Raffaele, Institute of Neurobiology and Molecular Medicine, Sapienza University of Rome
- SCStefano Chimenti
Università Campus Bio-Medico, Mario Negri Institute for Pharmacological Research, Istituto Neurologico Mediterraneo, IRCCS Ospedale San Raffaele, Institute of Neurobiology and Molecular Medicine, Sapienza University of Rome
Topics & keywords
- Stem cell
- Myocyte
- Biology
- Cell biology
- Endothelial stem cell
- Progenitor cell
- Transplantation
- Adult stem cell
- Good health and well-being