Quantitative multi-parameter mapping of R1, PD*, MT, and R2* at 3T: a multi-center validation
University College London · National Hospital for Neurology and Neurosurgery · +7 more institutions
Abstract
Multi-center studies using magnetic resonance imaging facilitate studying small effect sizes, global population variance and rare diseases. The reliability and sensitivity of these multi-center studies crucially depend on the comparability of the data generated at different sites and time points. The level of inter-site comparability is still controversial for conventional anatomical T1-weighted MRI data. Quantitative multi-parameter mapping (MPM) was designed to provide MR parameter measures that are comparable across sites and time points, i.e., 1 mm high-resolution maps of the longitudinal relaxation rate (R1 = 1/T1), effective proton density (PD(*)), magnetization transfer saturation (MT) and effective…
Citation impact
- FWCI
- 15.75
- Percentile
- 100%
- References
- 62
Authors
9- NWNikolaus WeiskopfCorresponding
University College London, National Hospital for Neurology and Neurosurgery, Wellcome Centre for Human Neuroimaging
- JSJohn Suckling
University of Cambridge, Cambridgeshire and Peterborough NHS Foundation Trust
- GWGuy Williams
University of Cambridge
- MCMarta Correia
MRC Cognition and Brain Sciences Unit
- BIBecky Inkster
University of Cambridge
Topics & keywords
- Statistics
- Reproducibility
- Comparability
- Mathematics
- Nuclear medicine
- Medicine