Analysis of Pseudomonas aeruginosa 4-hydroxy-2-alkylquinolines (HAQs) reveals a role for 4-hydroxy-2-heptylquinoline in cell-to-cell communication
Harvard University · Institut National de la Recherche Scientifique · +2 more institutions
Abstract
Bacterial communities use "quorum sensing" (QS) to coordinate their population behavior through the action of extracellular signal molecules, such as the N-acyl-l-homoserine lactones (AHLs). The versatile and ubiquitous opportunistic pathogen Pseudomonas aeruginosa is a well-studied model for AHL-mediated QS. This species also produces an intercellular signal distinct from AHLs, 3,4-dihydroxy-2-heptylquinoline (PQS), which belongs to a family of poorly characterized 4-hydroxy-2-alkylquinolines (HAQs) previously identified for their antimicrobial activity. Here we use liquid chromatography (LC)/MS, genetics, and whole-genome expression to investigate the structure, biosynthesis, regulation, and activity of…
Citation impact
- FWCI
- 7.83
- Percentile
- 100%
- References
- 44
Authors
7- ÉDÉric DézielCorresponding
Harvard University, Institut National de la Recherche Scientifique, Massachusetts General Hospital, Stanford University
- FLFrançois Lépine
Harvard University, Institut National de la Recherche Scientifique, Massachusetts General Hospital, Stanford University
- SMSylvain Milot
Harvard University, Institut National de la Recherche Scientifique, Massachusetts General Hospital, Stanford University
- JHJianxin He
Harvard University, Institut National de la Recherche Scientifique, Massachusetts General Hospital, Stanford University
- MMMichael Mindrinos
Harvard University, Institut National de la Recherche Scientifique, Massachusetts General Hospital, Stanford University
Topics & keywords
- Quorum sensing
- Pseudomonas aeruginosa
- Operon
- Cell signaling
- Biology
- Autoinducer
- Biochemistry
- Population
- Life in Land