Ten-Year Follow-Up of Radiation Therapy Oncology Group Protocol 92-02: A Phase III Trial of the Duration of Elective Androgen Deprivation in Locally Advanced Prostate Cancer
Fox Chase Cancer Center · Indiana University – Purdue University Indianapolis
Abstract
PURPOSE: To determine whether adding 2 years of androgen-deprivation therapy (ADT) improved outcome for patients electively treated with ADT before and during radiation therapy (RT). PATIENTS AND METHODS: Prostate cancer patients with T2c-T4 prostate cancer with no extra pelvic lymph node involvement and prostate-specific antigen (PSA) less than 150 ng/mL were included. All patients received 4 months of goserelin and flutamide before and during RT. They were randomized to no further ADT (short-term ADT [STAD] + RT) or 24 months of goserelin (long-term ADT [LTAD] + RT). A total of 1,554 patients were entered. RT was 45 Gy to the pelvic nodes and 65 to 70 Gy to the prostate. Median follow-up of all survival…
Citation impact
- FWCI
- 39.49
- Percentile
- 100%
- References
- 21
Authors
11- EMEric M. HorwitzCorresponding
Fox Chase Cancer Center, Indiana University – Purdue University Indianapolis
- KBKyounghwa Bae
Fox Chase Cancer Center, Indiana University – Purdue University Indianapolis
- GEGerald E. Hanks
Fox Chase Cancer Center, Indiana University – Purdue University Indianapolis
- ATArthur T. Porter
Fox Chase Cancer Center, Indiana University – Purdue University Indianapolis
- DJDavid J. Grignon
Fox Chase Cancer Center, Indiana University – Purdue University Indianapolis
Topics & keywords
- Medicine
- Prostate cancer
- Androgen deprivation therapy
- Goserelin
- Radiation therapy
- Urology
- Internal medicine
- Flutamide