Pulmonary Hypertension as a Risk Factor for Death in Patients with Sickle Cell Disease
National Institutes of Health Clinical Center · Center for Clinical Research (United States) · +3 more institutions
Abstract
The prevalence of pulmonary hypertension in adults with sickle cell disease, the mechanism of its development, and its prospective prognostic significance are unknown.
We performed Doppler echocardiographic assessments of pulmonary-artery systolic pressure in 195 consecutive patients (82 men and 113 women; mean [+/-SD] age, 36+/-12 years). Pulmonary hypertension was prospectively defined as a tricuspid regurgitant jet velocity of at least 2.5 m per second. Patients were followed for a mean of 18 months, and data were censored at the time of death or loss to follow-up.
Citation impact
- FWCI
- 33.70
- Percentile
- 100%
- References
- 42
Authors
16- MTMark T. GladwinCorresponding
National Institutes of Health Clinical Center, Center for Clinical Research (United States), National Institutes of Health, National Heart Lung and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases
- VSVandana Sachdev
National Heart Lung and Blood Institute
- MJMaria Jison
Center for Clinical Research (United States)
- YSYukitaka Shizukuda
National Heart Lung and Blood Institute
- JFJonathan F. Plehn
National Heart Lung and Blood Institute
Topics & keywords
- Medicine
- Disease
- Pulmonary hypertension
- Risk factor
- Prospective cohort study
- Mechanism (biology)
- Internal medicine
- Cardiology
- Good health and well-being