Prostaglandin E  2  Promotes Colon Cancer Cell Growth Through a G  s  -Axin-ß-Catenin Signaling Axis

Castellone, Maria Domenica; Teramoto, Hidemi; Williams, Bart O.; Druey, Kirk M.; Gutkind, J. Silvio

doi:10.1126/science.1116221

articleScienceNov 18, 2005Closed access

Prostaglandin E 2 Promotes Colon Cancer Cell Growth Through a G s -Axin-ß-Catenin Signaling Axis

MDMaria Domenica Castellone HTHidemi Teramoto BOBart O. Williams KMKirk M. Druey JSJ. Silvio Gutkind

Van Andel Institute · National Institute of Dental and Craniofacial Research · +2 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

How cyclooxygenase-2 (COX-2) and its proinflammatory metabolite prostaglandin E2 (PGE2) enhance colon cancer progression remains poorly understood. We show that PGE2 stimulates colon cancer cell growth through its heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptor, EP2, by a signaling route that involves the activation of phosphoinositide 3-kinase and the protein kinase Akt by free G protein betagamma subunits and the direct association of the G protein alphas subunit with the regulator of G protein signaling (RGS) domain of axin. This leads to the inactivation and release of glycogen synthase kinase 3beta from its complex with axin, thereby relieving the inhibitory phosphorylation…

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881

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FWCI: 37.13
Percentile: 100%
References: 39

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Topics & keywords

Topics

Keywords

Heterotrimeric G protein
Protein kinase B
Cell biology
Cancer research
Protein kinase A
Signal transduction
GSK-3
Regulator of G protein signaling

UN Sustainable Development Goals

Good health and well-being

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