Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins
Bio-oriented Technology Research Advancement Institution · Science and Technology Corporation (Norway) · +3 more institutions
Abstract
The Toll-like receptor (TLR) family acts as pattern recognition receptors for pathogen-specific molecular patterns (PAMPs). TLR2 is essential for the signaling of a variety of PAMPs, including bacterial lipoprotein/lipopeptides, peptidoglycan, and GPI anchors. TLR6 associates with TLR2 and recognizes diacylated mycoplasmal lipopeptide along with TLR2. We report here that TLR1 associates with TLR2 and recognizes the native mycobacterial 19-kDa lipoprotein along with TLR2. Macrophages from TLR1-deficient (TLR1(-/-)) mice showed impaired proinflammatory cytokine production in response to the 19-kDa lipoprotein and a synthetic triacylated lipopeptide. In contrast, TLR1(-/-) cells responded normally to diacylated…
Citation impact
- FWCI
- 20.07
- Percentile
- 100%
- References
- 24
Authors
8- OTOsamu TakeuchiCorresponding
Bio-oriented Technology Research Advancement Institution, Science and Technology Corporation (Norway), The University of Osaka
- SSShintaro Sato
Bio-oriented Technology Research Advancement Institution, Science and Technology Corporation (Norway), The University of Osaka
- THTakao Horiuchi
Bio-oriented Technology Research Advancement Institution, Science and Technology Corporation (Norway), The University of Osaka
- KHKatsuaki Hoshino
Bio-oriented Technology Research Advancement Institution, Science and Technology Corporation (Norway), The University of Osaka
- KTKiyoshi Takeda
Bio-oriented Technology Research Advancement Institution, Science and Technology Corporation (Norway), The University of Osaka
Topics & keywords
- Lipopeptide
- TLR2
- Pattern recognition receptor
- Receptor
- Peptidoglycan
- Microbiology
- Biology
- Toll-like receptor