Can Guideline-defined Asthma Control Be Achieved?
University of Cape Town · University of Southern Denmark · +3 more institutions
Abstract
For most patients, asthma is not controlled as defined by guidelines; whether this is achievable has not been prospectively studied. A 1-year, randomized, stratified, double-blind, parallel-group study of 3,421 patients with uncontrolled asthma compared fluticasone propionate and salmeterol/fluticasone in achieving two rigorous, composite, guideline-based measures of control: totally and well-controlled asthma. Treatment was stepped-up until total control was achieved (or maximum 500 microg corticosteroid twice a day). Significantly more patients in each stratum (previously corticosteroid-free, low- and moderate-dose corticosteroid users) achieved control with salmeterol/fluticasone than fluticasone. Total…
Citation impact
- FWCI
- 50.45
- Percentile
- 100%
- References
- 28
Authors
7- EDEric D. BatemanCorresponding
University of Cape Town, University of Southern Denmark, University of California, San Francisco, Ghent University Hospital, Kolding Hospital
- HAHomer A. Boushey
University of Cape Town, University of Southern Denmark, University of California, San Francisco, Ghent University Hospital, Kolding Hospital
- JBJean Bousquet
University of Cape Town, University of Southern Denmark, University of California, San Francisco, Ghent University Hospital, Kolding Hospital
- WWWilliam W. Busse
University of Cape Town, University of Southern Denmark, University of California, San Francisco, Ghent University Hospital, Kolding Hospital
- TJTim J. H. Clark
University of Cape Town, University of Southern Denmark, University of California, San Francisco, Ghent University Hospital, Kolding Hospital
Topics & keywords
- Salmeterol
- Fluticasone
- Medicine
- Fluticasone propionate
- Corticosteroid
- Guideline
- Asthma
- Internal medicine
- Good health and well-being