Cholesteryl Ester Transfer Protein
National Institutes of Health · Royal Adelaide Hospital · +4 more institutions
Abstract
Cholesteryl ester transfer protein (CETP) promotes the transfer of cholesteryl esters from antiatherogenic HDLs to proatherogenic apolipoprotein B (apoB)-containing lipoproteins, including VLDLs, VLDL remnants, IDLs, and LDLs. A deficiency of CETP is associated with increased HDL levels and decreased LDL levels, a profile that is typically antiatherogenic. Studies in rabbits, a species with naturally high levels of CETP, support the therapeutic potential of CETP inhibition as an approach to retarding atherogenesis. Studies in mice, a species that lacks CETP activity, have provided mixed results. Human subjects with heterozygous CETP deficiency and an HDL cholesterol level >60 mg/dL have a reduced risk of…
Citation impact
- FWCI
- 50.44
- Percentile
- 100%
- References
- 65
Authors
6- PJPhilip J. BarterCorresponding
National Institutes of Health, Royal Adelaide Hospital, Columbia University Irving Medical Center, National Heart Lung and Blood Institute, Hanson Institute
- HBH Bryan Brewer
National Institutes of Health, Columbia University Irving Medical Center, National Heart Lung and Blood Institute, University of Pennsylvania
- MJM. John Chapman
National Institutes of Health, Columbia University Irving Medical Center, National Heart Lung and Blood Institute, University of Pennsylvania
- CHCharles H. Hennekens
National Institutes of Health, Columbia University Irving Medical Center, National Heart Lung and Blood Institute, University of Pennsylvania
- DJDaniel J. Rader
National Institutes of Health, Royal Adelaide Hospital, Columbia University Irving Medical Center, National Heart Lung and Blood Institute, Hanson Institute
Topics & keywords
- Cholesterylester transfer protein
- Apolipoprotein B
- Internal medicine
- Cholesterol
- Endocrinology
- Very low-density lipoprotein
- Reverse cholesterol transport
- Chemistry
- Good health and well-being