Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

Mahajan, Anubha; Go, Min Jin; Zhang, Weihua; Below, Jennifer E.; Gaulton, Kyle J.; Ferreira, Teresa; Horikoshi, Momoko; Johnson, Andrew D.; Ng, Maggie C. Y.; Prokopenko, Inga; Saleheen, Danish; Wang, Xu; Zeggini, Eleftheria; Abecasis, Gonçalo R.; Adair, Linda S.; Almgren, Peter; Atalay, Mustafa; Aung, Tin; Baldassarre, Damiano; Balkau, Beverley; Bao, Yuqian; Barnett, Anthony; Barroso, Inês; Basit, Abdul; Been, Latonya; Beilby, John; Bell, Graeme I.; Benediktsson, Rafn; Bergman, Richard N.; Boehm, Bernhard O.; Boerwinkle, Eric; Bonnycastle, Lori L.; Burtt, Noël P.; Cai, Qiuyin; Campbell, Harry; Carey, Jason; Cauchi, Stéphane; Caulfield, Mark J.; Chan, Juliana C.N.; Chang, Li-Ching; Chang, Tien‐Jyun; Chang, Yi‐Cheng; Charpentier, G.; Chen, Chien-Hsiun; Chen, Han; Chen, Yuan-Tsong; Chia, Kee‐Seng; Chidambaram, Manickam; Chines, Peter S.; Cho, Nam H.; Cho, Young Min; Chuang, Lee‐Ming; Collins, Francis S.; Cornelis, Marilyn C.; Couper, David; Crenshaw, Andrew; Dam, Rob M. van; Danesh, John; Das, Debashish; Fairé, Ulf dé; Dedoussis, George; Deloukas, Panos; Dimas, Antigone S.; Dina, Christian; Doney, Alex S. F.; Donnelly, Peter; Dorkhan, Mozhgan; Duijn, Cornelia M. van; Dupuis, Josée; Edkins, Sarah; Elliott, Paul; Emilsson, Valur; Erbel, Raimund; Eriksson, Johan G.; Escobedo, Jorge; Esko, Tõnu; Eury, Elodie; Florez, José C.; Fontanillas, Pierre; Forouhi, Nita G.; Forsén, Tom; Fox, Caroline S.; Fraser, Ross M.; Frayling, Timothy M.; Froguel, Philippe; Frossard, Philippe; Gao, Yu‐Tang; Gertow, Karl; Gieger, Christian; Gigante, Bruna; Grallert, Harald; Grant, George; Groop, Leif; Groves, Christopher J.; Grundberg, Elin; Guiducci, Candace; Hamsten, Anders; Han, Bok‐Ghee; Hara, Kazuo; Hassanali, Neelam; Hattersley, Andrew T.; Hayward, Caroline; Hedman, Åsa K.; Herder, Christian; Hofman, Albert; Holmen, Oddgeir L.; Hovingh, Kees; Hreiðarsson, Ástráður B.; Hu, Cheng; Hu, Frank B.; Hui, Jennie; Humphries, Steve E.; Hunt, Sarah; Hunter, David J.; Hveem, Kristian; Hydrie, Muhammad Zafar Iqbal; Ikegami, Hiroshi; Illig, Thomas; Ingelsson, Erik; Islam, Muhammed; Isomaa, Bo; Jackson, Anne; Jafar, Tazeen; James, Alan; Jia, Weiping; Jöckel, Karl‐Heinz; Jonsson, Anna; Jowett, Jeremy B. M.; Kadowaki, Takashi; Kang, Hyun Min; Kanoni, Stavroula; Kao, Wen Hong Linda; Kathiresan, Sekar; Kato, Norihiro; Katulanda, Prasad; Keinänen‐Kiukaanniemi, Sirkka; Kelly, Ann M; Khan, Hassan; Khaw, Kay‐Tee; Khor, Chiea Chuen; Kim, Hyung-Lae; Kim, Sang Soo; Kim, Young Jin; Kinnunen, Leena; Klopp, Norman; Kong, Augustine; Korpi-Hyövälti, Eeva; Kowlessur, Sudhir; Kraft, Peter; Kravić, Jasmina; Kristensen, Malene M.; Krithika, S.; Kumar, Ashish; Kumate, J; Kuusisto, Johanna; Kwak, Soo Heon; Laakso, Markku; Lagou, Vasiliki; Lakka, Timo A.; Langenberg, Claudia; Langford, Cordelia; Lawrence, Robert; Leander, Karin; Lee, Jen-Mai; Lee, Sang; Li, Man; Li, Man; Li, Yun; Liang, Junbin; Liju, Samuel; Lim, Wei‐Yen; Lind, Lars; Lindgren, Cecilia M.; Lindholm, Eero; Liu, Ching‐Ti; Liu, Jianjun; Lobbens, Stéphane; Long, Jirong; Loos, Ruth J. F.; Lu, Wei; Luan, Jian’an; Lyssenko, Valeriya; C.W., Ronald; Maeda, Shiro; Mägi, Reedik; Männistö, Satu; Matthews, David R; Meigs, James B.; Melander, Olle; Metspalu, Andres; Meyer, Julia; Mirza, Ghazala; Mihailov, Evelin; Moebus, Susanne; Mohan, Viswanathan; Mohlke, Karen L.; Morris, Andrew D.; Mühleisen, Thomas W; Müller‐Nurasyid, Martina; Musk, Bill; Nakamura, Jiro; Nakashima, Eitaro; Navarro, Pau; Ng, Peng-Keat; Nica, Alexandra C.; Nilsson, Peter M.; Njølstad, Inger; Nöthen, Markus M.; Ohnaka, Keizo; Ong, Twee Hee; Owen, Katharine R.; Palmer, Colin N A; Pankow, James S.; Park, Kyong Soo; Parkin, Melissa; Pechlivanis, Sonali; Pedersen, Nancy L.; Peltonen, Leena; Perry, John R. B.; Peters, Annette; Pinidiyapathirage, Janani; Platou, Carl; Potter, Simon; Price, Jackie F.; Qi, Lu; Radha, Venkatesan; Rallidis, Lοukianos S.; Rasheed, Asif; Rathmann, Wolfgang; Rauramaa, Rainer; Raychaudhuri, Soumya; Rayner, Nigel W.; Rees, Simon D.; Rehnberg, Emil; Ripatti, Samuli; Robertson, Neil; Roden, Michael; Rossin, Elizabeth J.; Rudan, Igor; Rybin, Denis; Saaristo, Timo; Salomaa, Veikko; Saltevo, Juha; Samuel, Maria; Sanghera, Dharambir K.; Saramies, Jouko; Scott, James; Scott, Laura J.; Scott, Robert A.; Segrè, Ayellet V.; Sehmi, Joban; Sennblad, Bengt; Shah, Nabi; Shah, Sonia; Shera, A. Samad; Shu, Xiao Ou; Shuldiner, Alan R.; Sigurðsson, Gunnar; Sijbrands, Eric J.G.; Silveira, Angela; Sim, Xueling; Sivapalaratnam, Suthesh; Small, Kerrin S.; So, Wing Yee; Stančáková, Alena; Stefánsson, Kāri; Steinbach, Gerald; Steinthórsdóttir, Valgerður; Stirrups, Kathleen; Strawbridge, Rona J.; Stringham, Heather M.; Sun, Qi; Suo, Chen; Syvänen, Ann‐Christine; Takayanagi, Ryoichi; Takeuchi, Fumihiko; Tay, Wan Ting; Teslovich, Tanya M.; Thorand, Barbara; Þorleifsson, Guðmar; Þorsteinsdóttir, Unnur; Tikkanen, Emmi; Trakalo, Joseph; Tremoli, Elena; Trip, Mieke D.; Tsai, Fuu Jen; Tuomi, Tiinamaija; Tuomilehto, Jaakko; Uitterlinden, André G.; Valladares‐Salgado, Adán; Vedantam, Sailaja; Veglia, Fabrizio; Voight, Benjamin F.; Wang, Congrong; Wareham, Nicholas J.; Wennauer, Roman; Wickremasinghe, Ananda R.; Wilsgaard, Tom; Wilson, James F.; Wiltshire, Steven; Winckler, Wendy; Wong, Tien Yin; Wood, Andrew R.; Wu, Jer‐Yuarn; Wu, Ying; Yamamoto, Ken; Yamauchi, Toshimasa; Yang, Ming‐Yu; Yengo, Loïc; Yokota, Mitsuhiro; Young, Robin; Zabaneh, Delilah; Zhang, Fan; Zhang, Rong; Zheng, Wei; Zimmet, Paul; Altshuler, David; Bowden, Donald W.; Cho, Yoon Shin; Cox, Nancy J.; Cruz, Miguel; Hanis, Craig L.; Kooner, Jaspal S.; Lee, Jong‐Young; Seielstad, Mark; Teo, Yik Ying; Boehnke, Michael; Parra, Esteban J.; Chambers, John C.; Tai, E Shyong; McCarthy, Mark I.; Morris, Andrew P.

doi:10.1038/ng.2897

reviewNature GeneticsFeb 9, 2014BRONZE OA

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

AMAnubha Mahajan MJMin Jin Go WZWeihua Zhang JEJennifer E. Below KJKyle J. Gaulton

Centre for Human Genetics · University of Oxford · +163 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

No abstract available for this paper.

Citation impact

1,079

total citations

FWCI: 98.84
Percentile: 100%
References: 54

Citations per year

Authors

332

AM
Anubha Mahajan
Centre for Human Genetics, University of Oxford
MJ
Min Jin Go
Korea National Institute of Health
WZ
Weihua Zhang
Imperial College London
JE
Jennifer E. Below
University of Washington
KJ
Kyle J. Gaulton
Centre for Human Genetics, University of Oxford

Topics & keywords

Topics

Genetic Associations and Epidemiology100%
Genetic Mapping and Diversity in Plants and Animals100%
Genetic and phenotypic traits in livestock99%

Keywords

Genome-wide association study
Biology
Genetic architecture
Genetics
Genetic association
Single-nucleotide polymorphism
Genetic genealogy
Allele

UN Sustainable Development Goals

Good health and well-being

No related works found for this paper.

Funding

WT
Wellcome Trust
Awards: WT098017, WT090532
EC
European Commission
Awards: 201413, HEALTH-F4-2007-201413
CN
Consejo Nacional de Ciencia y Tecnología
IM
Instituto Mexicano del Seguro Social
ID
Instituto de Seguriidad y Servicios Sociales de los Trabadores del Estado
NI
National Institutes of Health
Awards: DK062370, HG000376, DK085584, DK073541, DK085501, DK085545
CI
Canadian Institutes of Health Research
MR
Medical Research Council
Awards: MR/K006584/1, MC_UU_12015/5, MR/L003120/1, MC_UU_12015/2, G0601261, MC_UU_12015/1
FH
FP7 Health
Awards: 201413, HEALTH-F4-2007-201413