Sustained Reductions in Invasive Pneumococcal Disease in the Era of Conjugate Vaccine

Pilishvili, Tamara; Lexau, Catherine; Farley, Monica M.; Hadler, James L.; Harrison, Lee H.; Bennett, Nancy M.; Reingold, Arthur; Thomas, Ann; Schaffner, William; Craig, Allen S.; Smith, Philip J; Beall, Bernard; Whitney, Cynthia G.; Moore, Matthew R.

doi:10.1086/648593

articleThe Journal of Infectious DiseasesNov 30, 2009BRONZE OA

Sustained Reductions in Invasive Pneumococcal Disease in the Era of Conjugate Vaccine

TPTamara Pilishvili CLCatherine Lexau MMMonica M. Farley JLJames L. Hadler LHLee H. Harrison

Centers for Disease Control and Prevention · Minnesota Department of Health · +10 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Background

Changes in invasive pneumococcal disease (IPD) incidence were evaluated after 7 years of 7-valent pneumococcal conjugate vaccine (PCV7) use in US children.

Methods

Laboratory-confirmed IPD cases were identified during 1998-2007 by 8 active population-based surveillance sites. We compared overall, age group-specific, syndrome-specific, and serotype group-specific IPD incidence in 2007 with that in 1998-1999 (before PCV7) and assessed potential serotype coverage of new conjugate vaccine formulations.

Results

Overall and PCV7-type IPD incidence declined by 45% (from 24.4 to 13.5 cases per 100,000 population) and 94% (from 15.5 to 1.0 cases per 100,000 population), respectively (P

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Authors

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Topics & keywords

Topics

Keywords

Pneumococcal disease
Pneumococcal conjugate vaccine
Pneumococcal infections
Streptococcus pneumoniae
Conjugate
Medicine
Virology
Conjugate vaccine

UN Sustainable Development Goals

Good health and well-being

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