Late Side Effects of Short-Course Preoperative Radiotherapy Combined With Total Mesorectal Excision for Rectal Cancer: Increased Bowel Dysfunction in Irradiated Patients—A Dutch Colorectal Cancer Group Study
University Medical Center Groningen · Radboud University Nijmegen · +5 more institutions
Abstract
PURPOSE: Preoperative short-term radiotherapy improves local control in patients treated with total mesorectal excision (TME). This study was performed to assess the presence and magnitude of long-term side effects of preoperative 5 x 5 Gy radiotherapy and TME. Also, hospital treatment was recorded for diseases possibly related to late side effects of rectal cancer treatment. PATIENTS AND METHODS: Long-term morbidity was assessed in patients from the prospective randomized TME trial, which investigated the efficacy of 5 x 5 Gy before TME surgery for mobile rectal cancer. Dutch patients without recurrent disease were sent a questionnaire. RESULTS: Results were obtained from 597 patients, with a median follow-up…
Citation impact
- FWCI
- 17.02
- Percentile
- 100%
- References
- 29
Authors
10- KPKoen Peeters
University Medical Center Groningen, Radboud University Nijmegen, University of Groningen, Leiden University Medical Center, Catharina Ziekenhuis, University Medical Center, Radboud University Medical Center
- CJCornelis J.�H. van de VeldeCorresponding
University Medical Center Groningen, Radboud University Nijmegen, University of Groningen, Leiden University Medical Center, Catharina Ziekenhuis, University Medical Center, Radboud University Medical Center
- JLJ.W.H. Leer
University Medical Center Groningen, Radboud University Nijmegen, University of Groningen, Leiden University Medical Center, Catharina Ziekenhuis, University Medical Center, Radboud University Medical Center
- HMHendrik Martijn
University Medical Center Groningen, Radboud University Nijmegen, University of Groningen, Leiden University Medical Center, Catharina Ziekenhuis, University Medical Center, Radboud University Medical Center
- JMJan M. C. Junggeburt
University Medical Center Groningen, Radboud University Nijmegen, University of Groningen, Leiden University Medical Center, Catharina Ziekenhuis, University Medical Center, Radboud University Medical Center
Topics & keywords
- Medicine
- Total mesorectal excision
- Colorectal cancer
- Radiation therapy
- Surgery
- Rectum
- Prospective cohort study
- Cancer
- Good health and well-being