Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer
Vita-Salute San Raffaele University · San Raffaele University of Rome · +1 more institution
Abstract
Pancreatic cancer is a very aggressive disease characterized by a marked desmoplasia with a predominant Th2 (GATA-3+) over Th1 (T-bet+) lymphoid infiltrate. We found that the ratio of GATA-3+/T-bet+ tumor-infiltrating lymphoid cells is an independent predictive marker of patient survival. Patients surgically treated for stage IB/III disease with a ratio inferior to the median value had a statistically significant prolonged overall survival, implying an active role for Th2 responses in disease progression. Thymic stromal lymphopoietin (TSLP), which favors Th2 cell polarization through myeloid dendritic cell (DC) conditioning, was secreted by cancer-associated fibroblasts (CAFs) after activation with…
Citation impact
- FWCI
- 22.94
- Percentile
- 100%
- References
- 50
Authors
10- LDLucia De Monte
Vita-Salute San Raffaele University, San Raffaele University of Rome, Pancreas Centre (Canada)
- MRMichele Reni
Vita-Salute San Raffaele University, San Raffaele University of Rome, Pancreas Centre (Canada)
- ETElena Tassi
Vita-Salute San Raffaele University, San Raffaele University of Rome, Pancreas Centre (Canada)
- DCDaniela Clavenna
Vita-Salute San Raffaele University, San Raffaele University of Rome, Pancreas Centre (Canada)
- IPIlenia Papa
Vita-Salute San Raffaele University, San Raffaele University of Rome, Pancreas Centre (Canada)
Topics & keywords
- Thymic stromal lymphopoietin
- Pancreatic cancer
- Stromal cell
- Cancer research
- Tumor microenvironment
- Immunology
- Biology
- Chemokine
- Good health and well-being