Regulation of an ATG7 - beclin 1 Program of Autophagic Cell Death by Caspase-8
National Institutes of Health · Biotechnology Institute · +3 more institutions
Abstract
Caspases play a central role in apoptosis, a well-studied pathway of programmed cell death. Other programs of death potentially involving necrosis and autophagy may exist, but their relation to apoptosis and mechanisms of regulation remains unclear. We define a new molecular pathway in which activation of the receptor-interacting protein (a serine-threonine kinase) and Jun amino-terminal kinase induced cell death with the morphology of autophagy. Autophagic death required the genes ATG7 and beclin 1 and was induced by caspase-8 inhibition. Clinical therapies involving caspase inhibitors may arrest apoptosis but also have the unanticipated effect of promoting autophagic cell death.
Citation impact
- FWCI
- 48.95
- Percentile
- 100%
- References
- 27
Authors
8- LYLi Yu
National Institutes of Health, Biotechnology Institute, MRC Weatherall Institute of Molecular Medicine, National Institute of Allergy and Infectious Diseases, University of Maryland, College Park
- AAAjjai Alva
National Institutes of Health, Biotechnology Institute, MRC Weatherall Institute of Molecular Medicine, National Institute of Allergy and Infectious Diseases, University of Maryland, College Park
- HCHelen C. Su
National Institutes of Health, Biotechnology Institute, MRC Weatherall Institute of Molecular Medicine, National Institute of Allergy and Infectious Diseases, University of Maryland, College Park
- PDParmesh Dutt
National Institutes of Health, Biotechnology Institute, MRC Weatherall Institute of Molecular Medicine, National Institute of Allergy and Infectious Diseases, University of Maryland, College Park
- ECEric C. Freundt
National Institutes of Health, Biotechnology Institute, MRC Weatherall Institute of Molecular Medicine, National Institute of Allergy and Infectious Diseases, University of Maryland, College Park
Topics & keywords
- Autophagy
- Programmed cell death
- Cell biology
- Caspase
- Apoptosis
- Kinase
- Serine
- Necrosis
- Good health and well-being