A Randomized Trial of Deep-Brain Stimulation for Parkinson's Disease
Christian-Albrechts-Universität zu Kiel
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Abstract
Background
Neurostimulation of the subthalamic nucleus reduces levodopa-related motor complications in advanced Parkinson's disease. We compared this treatment plus medication with medical management.
Methods
In this randomized-pairs trial, we enrolled 156 patients with advanced Parkinson's disease and severe motor symptoms. The primary end points were the changes from baseline to six months in the quality of life, as assessed by the Parkinson's Disease Questionnaire (PDQ-39), and the severity of symptoms without medication, according to the Unified Parkinson's Disease Rating Scale, part III (UPDRS-III).
Citation impact
2,929
total citations
- FWCI
- 62.82
- Percentile
- 100%
- References
- 33
Citations per year
Authors
38Topics & keywords
Topics
Keywords
- Medicine
- Neurostimulation
- Deep brain stimulation
- Parkinson's disease
- Subthalamic nucleus
- Randomized controlled trial
- Adverse effect
- Quality of life (healthcare)
UN Sustainable Development Goals
- Good health and well-being
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