A core gut microbiome in obese and lean twins

Turnbaugh, Peter J.; Hamady, Micah; Yatsunenko, Tanya; Cantarel, Brandi L.; Duncan, Alexis E.; Ley, Ruth E.; Sogin, Mitchell L.; Jones, William J.; Roe, Bruce A.; Affourtit, Jason P.; Miller, Michael D.; Henrissat, Bernard; Heath, Andrew C.; Knight, Rob; Gordon, Jeffrey I.

doi:10.1038/nature07540

articleNatureNov 30, 2008GOLD OA

A core gut microbiome in obese and lean twins

PJPeter J. Turnbaugh MHMicah Hamady TYTanya Yatsunenko BLBrandi L. Cantarel AEAlexis E. Duncan

Washington University in St. Louis · Centre National de la Recherche Scientifique · +5 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

The many 'friendly' microbes that inhabit the human gut have been implicated in numerous health-related issues, in particular those involving digestion and susceptibility to infection. A study of the faecal microbial communities of pairs of adult female twins, selected to include 'lean' and 'obese' individuals, reveals some similarities between the human gut microbiomes among family members, but each person's gut microbial community varies in the specific bacterial lineages present. There was a wide array of shared microbial genes among individuals, comprising an identifiable 'core microbiome' at the gene, rather than at the microbial species level. This core includes many novel genes for carbohydrate…

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Topics & keywords

Topics

Keywords

Microbiome
Biology
Metagenomics
Gut flora
Genetics
Lineage (genetic)
Zoology
Gene

UN Sustainable Development Goals

Affordable and clean energy

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