Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity
The Honourable Society of Lincoln's Inn · The Francis Crick Institute · +4 more institutions
Abstract
The mechanisms by which melanoma and other cancer cells evade anti-tumor immunity remain incompletely understood. Here, we show that the growth of tumors formed by mutant Braf(V600E) mouse melanoma cells in an immunocompetent host requires their production of prostaglandin E2, which suppresses immunity and fuels tumor-promoting inflammation. Genetic ablation of cyclooxygenases (COX) or prostaglandin E synthases in Braf(V600E) mouse melanoma cells, as well as in Nras(G12D) melanoma or in breast or colorectal cancer cells, renders them susceptible to immune control and provokes a shift in the tumor inflammatory profile toward classic anti-cancer immune pathways. This mouse COX-dependent inflammatory signature is…
Citation impact
- FWCI
- 33.04
- Percentile
- 100%
- References
- 53
Authors
12- SZSantiago ZelenayCorresponding
The Honourable Society of Lincoln's Inn, The Francis Crick Institute
- AGAnnemarthe G. van der Veen
The Honourable Society of Lincoln's Inn, The Francis Crick Institute
- JPJan P. Böttcher
The Honourable Society of Lincoln's Inn, The Francis Crick Institute
- KJKathryn J. Snelgrove
The Honourable Society of Lincoln's Inn, The Francis Crick Institute
- NCNeil C. Rogers
The Honourable Society of Lincoln's Inn, The Francis Crick Institute
Topics & keywords
- Biology
- Evasion (ethics)
- Immunity
- Cyclooxygenase
- Immunology
- Cell biology
- Immune system
- Enzyme