Prognostic Factors and Life Expectancy in Myelodysplastic Syndromes Classified According to WHO Criteria: A Basis for Clinical Decision Making
University of Pavia · Policlinico San Matteo Fondazione · +1 more institution
Abstract
PURPOSE: The aim of this study was to evaluate the prognostic value of the WHO proposal, to assess the role of the main prognostic factors in myelodysplastic syndromes (MDSs) classified into WHO subgroups, and to estimate mortality (standardized mortality ratio [SMR]) and life expectancy in these groups as a basis for clinical decision making. PATIENTS AND METHODS: Four hundred sixty-seven patients who were diagnosed as having de novo MDS at the Division of Hematology, University of Pavia (Pavia, Italy), between 1992 and 2002, were evaluated retrospectively for clinical and hematologic features at diagnosis, overall survival (OS), and progression to leukemia (leukemia-free survival). RESULTS: Significant…
Citation impact
- FWCI
- 22.44
- Percentile
- 100%
- References
- 28
Authors
12- LMLuca Malcovati
University of Pavia, Policlinico San Matteo Fondazione, Istituti di Ricovero e Cura a Carattere Scientifico
- MGMatteo Giovanni Della Porta
University of Pavia, Policlinico San Matteo Fondazione, Istituti di Ricovero e Cura a Carattere Scientifico
- CPCristiana Pascutto
University of Pavia, Policlinico San Matteo Fondazione, Istituti di Ricovero e Cura a Carattere Scientifico
- RIRosangela Invernizzi
University of Pavia, Policlinico San Matteo Fondazione, Istituti di Ricovero e Cura a Carattere Scientifico
- MBMarina Boni
University of Pavia, Policlinico San Matteo Fondazione, Istituti di Ricovero e Cura a Carattere Scientifico
Topics & keywords
- Medicine
- Myelodysplastic syndromes
- Life expectancy
- Clinical decision making
- Oncology
- Pediatrics
- Intensive care medicine
- Internal medicine
- Good health and well-being