Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression
University of California, Irvine · University of Michigan · +2 more institutions
Abstract
Abnormalities in L-glutamic acid (glutamate) and GABA signal transmission have been postulated to play a role in depression, but little is known about the underlying molecular determinants and neural mechanisms. Microarray analysis of specific areas of cerebral cortex from individuals who had suffered from major depressive disorder demonstrated significant down-regulation of SLC1A2 and SLC1A3, two key members of the glutamate/neutral amino acid transporter protein family, SLC1. Similarly, expression of L-glutamate-ammonia ligase, the enzyme that converts glutamate to nontoxic glutamine was significantly decreased. Together, these changes could elevate levels of extracellular glutamate considerably, which is…
Citation impact
- FWCI
- 6.95
- Percentile
- 100%
- References
- 48
Authors
11- PVPrabhakara V. ChoudaryCorresponding
University of California, Irvine, University of Michigan, University of California, Davis, Stanford University
- MMMargherita Molnar
University of California, Irvine, University of Michigan, University of California, Davis, Stanford University
- SJSimon J. Evans
University of California, Irvine, University of Michigan, University of California, Davis, Stanford University
- HTHiroaki Tomita
University of California, Irvine, University of Michigan, University of California, Davis, Stanford University
- JLJianan Li
University of California, Irvine, University of Michigan, University of California, Davis, Stanford University
Topics & keywords
- Glutamate receptor
- Glutamatergic
- Glutamine
- GABAergic
- Neuroscience
- Biology
- Glutaminase
- Metabotropic glutamate receptor
- Good health and well-being