ConSurf: Identification of Functional Regions in Proteinsby Surface-Mapping of Phylogenetic Information

Abstract Summary: We recently developed algorithmic tools for the identification of functionally important regions in proteins of known three dimensional structure by estimating the degree of conservation of the amino-acid sites among their close sequence homologues. Projecting the conservation grades onto the molecular surface of these proteins reveals patches of highly conserved (or occasionally highly variable) residues that are often of important biological function. We present a new web server, ConSurf, which automates these algorithmic tools. ConSurf may be used for high-throughput characterization of functional regions in proteins. Availability: The ConSurf web server is available…

• NS
  National Science Foundation
• IC
  Israel Cancer Research Fund
• TA
  Tel Aviv University
• JS
  Japan Society for the Promotion of Science
• DO
  Division of Undergraduate Education