Voxel-Based Morphometry of the Human Brain: Methods and Applications

In recent years, a whole-brain unbiased objective technique, known as voxel-based morphometry (VBM), has been developed to characterise brain differences in vivo using structural magnetic resonance images. The present review provides a brief description of VBM and then focuses on exemplar applications in healthy and diseased subjects. The procedure involves normalising high-resolution structural magnetic resonance images to a standard template in stereotactic space. Normalised images are then segmented into gray and white matter and smoothed using an isotropic Gaussian kernel. Finally, a series of voxel-wise comparisons of gray and white matter in different groups of subjects are performed, using Random Field…

• WT
  Wellcome Trust