Complete Genome Sequence of the Apicomplexan, Cryptosporidium parvum
Tufts University · University of Minnesota · +6 more institutions
Abstract
The apicomplexan Cryptosporidium parvum is an intestinal parasite that affects healthy humans and animals, and causes an unrelenting infection in immunocompromised individuals such as AIDS patients. We report the complete genome sequence of C. parvum , type II isolate. Genome analysis identifies extremely streamlined metabolic pathways and a reliance on the host for nutrients. In contrast to Plasmodium and Toxoplasma , the parasite lacks an apicoplast and its genome, and possesses a degenerate mitochondrion that has lost its genome. Several novel classes of cell-surface and secreted proteins with a potential role in host interactions and pathogenesis were also detected. Elucidation of the core metabolism,…
Citation impact
- FWCI
- 42.75
- Percentile
- 100%
- References
- 27
Authors
20- MSMitchell S. AbrahamsenCorresponding
Tufts University, University of Minnesota, Cornell University, Texas A&M University
- TJThomas J. TempletonCorresponding
Tufts University, University of Minnesota, Cornell University, Texas A&M University
- SEShinichiro Enomoto
Tufts University, University of Minnesota, Cornell University, Texas A&M University
- JEJuan E. Abrahante
Tufts University, University of Minnesota, Cornell University, Texas A&M University
- GZGuan Zhu
Tufts University, University of Minnesota, Cornell University, Texas A&M University
Topics & keywords
- Cryptosporidium parvum
- Apicoplast
- Biology
- Genome
- Cryptosporidium
- Apicomplexa
- Gene
- Whole genome sequencing
- Good health and well-being