Nitric oxide, oxidants, and protein tyrosine nitration

The occurrence of protein tyrosine nitration under disease conditions is now firmly established and represents a shift from the signal transducing physiological actions of • NO to oxidative and potentially pathogenic pathways. Tyrosine nitration is mediated by reactive nitrogen species such as peroxynitrite anion (ONOO – ) and nitrogen dioxide ( • NO 2 ), formed as secondary products of • NO metabolism in the presence of oxidants including superoxide radicals ( \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document}…

• HH
  Howard Hughes Medical Institute
• JS
  John Simon Guggenheim Memorial Foundation
• NI
  National Institutes of Health
• FI
  Fogarty International Center