Lysosomal Glycosphingolipid Recognition by NKT Cells
Brigham Young University · Scripps Research Institute · +3 more institutions
Abstract
NKT cells represent a distinct lineage of T cells that coexpress a conserved alphabeta T cell receptor (TCR) and natural killer (NK) receptors. Although the TCR of NKT cells is characteristically autoreactive to CD1d, a lipid-presenting molecule, endogenous ligands for these cells have not been identified. We show that a lysosomal glycosphingolipid of previously unknown function, isoglobotrihexosylceramide (iGb3), is recognized both by mouse and human NKT cells. Impaired generation of lysosomal iGb3 in mice lacking beta-hexosaminidase b results in severe NKT cell deficiency, suggesting that this lipid also mediates development of NKT cells in the mouse. We suggest that expression of iGb3 in peripheral tissues…
Citation impact
- FWCI
- 32.55
- Percentile
- 100%
- References
- 30
Authors
17- DZDapeng ZhouCorresponding
Brigham Young University, Scripps Research Institute, University of Chicago, National Institute of Diabetes and Digestive and Kidney Diseases, University of Gothenburg
- JMJochen Mattner
Brigham Young University, Scripps Research Institute, University of Chicago, National Institute of Diabetes and Digestive and Kidney Diseases, University of Gothenburg
- CCCarlos Cantu
Brigham Young University, Scripps Research Institute, University of Chicago, National Institute of Diabetes and Digestive and Kidney Diseases, University of Gothenburg
- NSNicolas Schrantz
Brigham Young University, Scripps Research Institute, University of Chicago, National Institute of Diabetes and Digestive and Kidney Diseases, University of Gothenburg
- NYNing Yin
Brigham Young University, Scripps Research Institute, University of Chicago, National Institute of Diabetes and Digestive and Kidney Diseases, University of Gothenburg
Topics & keywords
- Natural killer T cell
- CD1D
- Glycosphingolipid
- Biology
- T-cell receptor
- CD1
- Cell biology
- Immunology
- Good health and well-being